Identification of Differentiation-Associated Brain-Specific Phosphate Transporter as a Second Vesicular Glutamate Transporter (VGLUT2)
نویسندگان
چکیده
منابع مشابه
Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).
Glutamate is the major excitatory neurotransmitter in mammalian CNS. In the presynaptic nerve terminal, glutamate is stored in synaptic vesicles and released by exocytosis. Previously, it has been shown that a transport protein originally identified as a brain-specific Na(+)-dependent inorganic phosphate transporter I (BNPI) functions as vesicular glutamate transporter and thus has been renamed...
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Glutamate transport into synaptic vesicles is a prerequisite for its regulated neurosecretion. Here we functionally identify a second isoform of the vesicular glutamate transporter (VGLUT2) that was previously identified as a plasma membrane Na+-dependent inorganic phosphate transporter (differentiation-associated Na+/P(I) transporter). Studies using intracellular vesicles from transiently tran...
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We studied the immunoreactive expression pattern for the vesicular glutamate transporter VGLUT2 in the embryonic, postnatal and adult mouse dorsal claustrum, at the light and electron microscopic levels. VGLUT2 immunoreactivity in the dorsal claustrum starts to be observed at E16.5, with a dramatic increase towards P0. At this age, abundant VGLUT2-immunoreactive axons and puncta are observed in...
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The auditory cortex of primates contains 13 areas distributed among 3 hierarchically connected regions: core, belt, and parabelt. Thalamocortical inputs arise in parallel from four divisions of the medial geniculate complex (MGC), which have regionally distinct projection patterns. These inputs terminate in layers IIIb and/or IV, and are assumed to be glutamatergic, although this has not been v...
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Vesicular glutamate transporter is present in neuronal synaptic vesicles and endocrine synaptic-like microvesicles and is responsible for vesicular storage of L-glutamate. A brain-specific Na(+)-dependent inorganic phosphate transporter (BNPI) functions as a vesicular glutamate transporter in synaptic vesicles, and the expression of this BNPI defines the glutamatergic phenotype in the central n...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2001
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.21-22-j0002.2001